Salirasib is a synthetic farnesylcysteine mimetic that inhibits ras proteins via disruption of interactions between the S-Prenyl moiety of Ras and the membrane anchorage domains. It has been investigated in the treatment of various cancers. HCC cells pretreated with salirasib were sensitized to...
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Salirasib is a synthetic farnesylcysteine mimetic that inhibits ras proteins via disruption of interactions between the S-Prenyl moiety of Ras and the membrane anchorage domains. It has been investigated in the treatment of various cancers. HCC cells pretreated with salirasib were sensitized to TRAIL-induced apoptosis. Salirasib has also been shown to inhibit TRPA1 (EC50 = 1.3 µM)
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