Potent and selective inhibitor of Src family kinases, IC50=4-10 nM for Src, c-Yes, Fyn, Lyn, Blk, Fgr and Lck. Demonstrates potent antimigratory, anti-invasive and antiproliferative activity and inhibits metastasis in a mouse model of bladder cancer. Inhibits MERS-CoV at early stages of the...
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Potent and selective inhibitor of Src family kinases, IC50=4-10 nM for Src, c-Yes, Fyn, Lyn, Blk, Fgr and Lck. Demonstrates potent antimigratory, anti-invasive and antiproliferative activity and inhibits metastasis in a mouse model of bladder cancer. Inhibits MERS-CoV at early stages of the viral life cycle at mM concentrations. Rescues memory performance and reduces phospho-Tau accumulation in traumatic tauopathy. Rescues memory deficits and synaptic depletion in an Alzheimer’s mouse model
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