Inhibitor of the nuclear export receptor CRM1/XPO1 Selinexor is a first-in-class chemotherapeutic, functioning by binding to Exportin-1 (XPO1, CRM1), a nuclear membrane-associated protein that aids transport of proteins into the cytoplasm. It also helps maintain chromosome structure. Inhibition...
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Inhibitor of the nuclear export receptor CRM1/XPO1
Selinexor is a first-in-class chemotherapeutic, functioning by binding to Exportin-1 (XPO1, CRM1), a nuclear membrane-associated protein that aids transport of proteins into the cytoplasm. It also helps maintain chromosome structure. Inhibition of these functions in cancer cells results in sensitization to DNA damaging agents, cell cycle arrest, and apoptosis. For example, it suppresses growth of T-cell acute lymphoblastic leukemia (T-ALL) cells (IC50 = 34-203 nM), and pancreatic cancer cells (IC50 ~ 150 nM). Currently in clinical trials for COVID-19 because of its ability to reduce inflammation
This product is manufactured by TriBio Science and sold through ABMIUM without relabelling.
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