A specific and potent autophagy inhibitor. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific proteases USP10 and USP13 which target the Beclin-1 subunit of Vps34 complexes. Deranges dengue virion maturation. Inhibits autophagy in a Beclin-1...
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A specific and potent autophagy inhibitor. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific proteases USP10 and USP13 which target the Beclin-1 subunit of Vps34 complexes. Deranges dengue virion maturation. Inhibits autophagy in a Beclin-1 independent manner in primary epithelial ovarian cancer cells. Selectively induces cell death of mutant p53-expressing cancer cell lines under confluency. Cell permeable
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