Metabolite of the cyclooxygenase inhibitor sulindac that induces apoptosis via inhibition of type 5 phosphodiesterases. Sulindac sulfone does not inhibit cyclooxygenase at physiological concentrations but does inhibit K-ras-dependent cyclooxygenase-2 expression in colon cancer cells
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Metabolite of the cyclooxygenase inhibitor sulindac that induces apoptosis via inhibition of type 5 phosphodiesterases. Sulindac sulfone does not inhibit cyclooxygenase at physiological concentrations but does inhibit K-ras-dependent cyclooxygenase-2 expression in colon cancer cells
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