Potent and selective inhibitor of both murine and human soluble epoxide hydrolase, IC 50 =2.8 and 3.7 nM respectively. It alleviated blood brain barrier damage and attenuated neuronal injury in a mouse intracerebral hemorrhage model and displays neuroprotective effects in ischemic injury. It...
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Potent and selective inhibitor of both murine and human soluble epoxide hydrolase, IC 50 =2.8 and 3.7 nM respectively. It alleviated blood brain barrier damage and attenuated neuronal injury in a mouse intracerebral hemorrhage model and displays neuroprotective effects in ischemic injury. It reduces neuroinflammation in a mouse model of Alzheimer’s disease. It improves insulin resistance and reduced hypertension in mouse models. Cell permeable and active in vivo
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