A indoloquinazoline alkaloid found in various plant species and possessing intriguing pharmacological activities.1 Suppresses activation of BV2 microglia cells following LPS treatment and reduces production of proinflammatory cytokines via Nrf2, HO-1 and NFκB signaling. Displays antiinflammatory...
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A indoloquinazoline alkaloid found in various plant species and possessing intriguing pharmacological activities.1 Suppresses activation of BV2 microglia cells following LPS treatment and reduces production of proinflammatory cytokines via Nrf2, HO-1 and NFκB signaling. Displays antiinflammatory activity targeting IL-17. Inhibits indoleamine 2,3-dioxygenase 2 (IDO2) with an IC50 of 5-17 μM. Induces growth inhibition and neuronal differentiation in human neuroblastoma LA-N-1 cells
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