Blocker of the inward rectifier potassium channel K ir 4.1 (IC 50 = 970 nM). It also inhibits K ir 3.1/3.2, K ir 3.1/3.4, and K ir 4.2 with similar potency. VU0134992 induced diuresis, natriuresis, and kaliuresis in Sprague-Dawley rats suggesting therapeutic blood pressure lowering potential. It...
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Blocker of the inward rectifier potassium channel K ir 4.1 (IC 50 = 970 nM). It also inhibits K ir 3.1/3.2, K ir 3.1/3.4, and K ir 4.2 with similar potency. VU0134992 induced diuresis, natriuresis, and kaliuresis in Sprague-Dawley rats suggesting therapeutic blood pressure lowering potential. It reduced polymyxin-induced nephrotoxicity in cell culture and mouse explant kidney tissue
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