A selective, reversible inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) activity. Binds to the regulatory domain of N-WASP and inhibits activation of Arp2/3 complex by forcing N-WASP into an inactive conformation. Inhibits PIP2-induced actin polymerization (EC50=4 μM). Perturbs...
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A selective, reversible inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) activity. Binds to the regulatory domain of N-WASP and inhibits activation of Arp2/3 complex by forcing N-WASP into an inactive conformation. Inhibits PIP2-induced actin polymerization (EC50=4 μM). Perturbs agrin-elicited acetylcholine receptor clustering. Inhibits the formation of dendritic spines and synapses in hippocampal neurons
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