A novel small molecule survivin suppressant. YM-155 suppresses expression of survivin (a member of the IAP family) and induced apoptosis in human tumor cell lines at 10 nmol/L with little effect on other IAP or Bcl-2 family members. Overcomes erlotinib resistance in EGFR mutation-positive...
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A novel small molecule survivin suppressant. YM-155 suppresses expression of survivin (a member of the IAP family) and induced apoptosis in human tumor cell lines at 10 nmol/L with little effect on other IAP or Bcl-2 family members. Overcomes erlotinib resistance in EGFR mutation-positive non-small cell lung cancer. Induces DNA damage. Induces an autophagy-dependent cell death in adenoid cystic carcinoma cells
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